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The absorption of zinc may be reduced by iron supplements, penicillamine, phosphorous-containing preparations, and tetracyclines. Zinc supplements reduce the absorption of copper, fluoroquinolones, iron, penicillamine, and tetracyclines.
Absorption of zinc from the gastrointestinal tract is incomplete, and is reduced in the presence of some dietary constituents such as phytates. Bioavailability of dietary zinc varies widely from about 20 to 30% but it highest in the presence of chelate-forming ions like ascorbate and gluconate.
